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PROJECT ZERO MIND PATHWAY MAPPING

THE PROBLEM
When researching complex systems subjects like cognitive decline, the researchers mind and teams of researchers minds are soon overwhelmed.  Without resorting to modeling via map and systems then heuristics, local minima thinking and bias will take over.  Science methods alone without complex mapping just improve on this by enabling very accurate local minima thinking which can join up with other teams local minima thinking later. Hopefully the bigger picture will emerge, but hundreds of international teams can still be stuck in the same minima and this is one reason why current research is very slow.
Systems theory mapping is now being employed but the uptake by the main research body is still very slow.  An application in this project is given hundreds of contradicting theories, targets and methods covering every facet of the mind how are we to simplify the problem of treatments ?  SENS framework proposes its 7 pillars of ageing underlie most age related diseases including…
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BREDESEN PROTOCOL AND SENS FRAMEWORK

Cognitive decline is a sub discipline of Alzheimer's research and so benefits from a vast amount of clinical research which covers almost every known facet of the mind.  The approach employed here will be based on a refinement of the well known "Bredesen Protocol".   
https://www.drbredesen.com/thebredesenprotocol
The Bredesen Protocol is the only treatment which has reversed cognitive decline safely and consistently in clinical trials.   This approach posits Cognitive decline as a multi-factorial systems problem and targets each system with a separate treatment in combination. Many of these treatments involve simple and diet lifestyle adjustments while others involve readily available drugs and treatments.   This protocol is complex and extremely hard for those experiencing dementia to adhere to,  but is ideally suited for a younger age group aiming to address the problem at an early stage.  


One of the aims of this project will be to refine and simplify the protocol for a…

BIOLOGICAL TARGETS AND METHODS LIST JANUARY 2018

BIOLOGICAL TARGETS AND METHODS LIST JANUARY 2018

This list still has more to be added from various treatment repositories, then will be pruned down.  See the project page for details of when this will be updated.


Biology hierarchy Within CNS; Most of these for SENS, 1__Cell loss, cell atrophy (below) Where necessary differentiate between, Myelination, Synaptogeneis, Neurogenesis, Gliosis
            Frontal cortex                         Neuron sub populations Bacopa monniera (BREDESEN) (von economo ?) sensitive neurons ? acethycholine Pantothenic acid (BREDESEN)             General white matter PPARg and PPARa  activation                                                 BACE inhibition                                                 Cortisol reduction                                                 Exercise sensitizes insulin receptors and increase growth factor IGF1 Chelator, antioxidant to control iron-related free radical toxicity, increase plasmalogens (PI) DHA for PI and Peroxisome proliferators …

PROJECT ZERO MIND DEVELOPMENT TIMELINE

STAGE 1 SETUP Jan 2018 to May 2018
Model building stage (to be published)Base Lab setupFormal definition of problem (to be published)How to measure and target problem (to be published)
STAGE 2 TRIAL RUNMay 2018 to January 2019
Initial working group setupOnline collaboration and monitoring systemInitial treatment regiments and methods agreed (to be published)
STAGE 3 CONSOLIDATE RESULTS January 2019
Collate dataStatisticsReport summary of results (to be published)

PROJECT BACKGROUND

Project zero MIND is an attempt to research and clinically evaluate treatment protocols that halt mid life neurodegeneration.   It is partly based on the findings of the late Dr George Bartzokis (1956-2014) UCLA Semel Institute for Neuroscience and Human Behavior 
http://newsroom.ucla.edu/stories/in-memoriam:-dr-george-bartzokis-neuroscientist-who-developed-the-myelin-model-of-brain-disease
Bartzokis key finding was that the brains myelination repair processes start to break down measurably from about age 35, causing us to become slower, less flexible and more forgetful.  More importantly he noticed that the pattern of degeneration across the brain in which this occurs start in the more complex and newly evolved areas (frontal lobe first) and progress in a way that actually resembles stages of dementia.


The types of proteins and the large volume of biological material involved in myelin breakdown are also implicated in overloading the brains neuroimmune system.   This overload is likely…

PROJECT ZERO MIND INTRODUCTION

Are you aged over 35 ? Have you perceived yourself to be less sharp, more forgetful, less cognitively flexible and less open to fundamental change than previously ?

Because neurodegeneration starts in mid life and gradually increases over time, many of us don’t notice this till our 50’s and beyond.   During this gradual process most of can manage fine with acceptance and mental heuristics. Such as refining learned methods further and couching our inflexibility as a necessary part of maintaining our responsibilities and socioeconomic position.
But what if we could actually slow this degeneration ? Would we actually find our progress accelerating and in the process become less prone to obsolescence? Would our mind be in far better condition for the future ?


For further information see

PROJECT BACKGROUND
PROJECT DEVELOPMENT TIMELINE
BIOLOGICAL TARGETS AND METHODS LIST
BREDESEN PROTOCOL AND SENS FRAMEWORK
PAPERS REPOSITORY  (Still to be added)
EVALUATION PROTOCOLS (Still to be added)
TRIAL PLATFO…