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BIOLOGICAL TARGETS AND METHODS LIST JANUARY 2018



BIOLOGICAL TARGETS AND METHODS LIST JANUARY 2018

This list still has more to be added from various treatment repositories, then will be pruned down.  See the project page for details of when this will be updated.

Biology hierarchy
Within CNS; Most of these for SENS, 1__Cell loss, cell atrophy (below)
Where necessary differentiate between, Myelination, Synaptogeneis, Neurogenesis, Gliosis

            Frontal cortex
                        Neuron sub populations
                                    Bacopa monniera (BREDESEN)
(von economo ?)
sensitive neurons ?
acethycholine
            Pantothenic acid (BREDESEN)
            General white matter
                                                PPARg and PPARa  activation
                                                BACE inhibition
                                                Cortisol reduction
                                                Exercise sensitizes insulin receptors and increase growth factor IGF1
Chelator, antioxidant to control iron-related free radical toxicity, increase plasmalogens (PI)
                                                    DHA for PI and Peroxisome proliferators activated receptors (PPAR) activation
                                                Increase brain ApoE levels (extra cellular junk removal ??)

            General neurogenesis
                        magnesium L-threonate (BREDESEN)
            H. erinaceus or ALCAR (BREDESEN)
                                    Sunlight – Vit D3 - K2 –NGF factor (BREDESEN)
            General synaptogenesis
                        Citicoline, DHA (BREDESEN)

Vascular
            Microglia
           
                       
Interaction between adaptive immunity and neuroimmunity - meningeal lymphatic vessels
            Omega 3
            Anti-inflammatory diet
            Vit D receptors in choroid plexus (NGF factor ??)
           
Within PNS and below: Most of these for 5__Immuno and cell senescence   (below)

From organs to BBB
                        Gut biome modification for gut leaking
                        Urea reduction ?? NOTE:  increased by ketogenesis
                        Oral hygeine
            General stress reduction
            Ashwagandha   (BREDESEN)
            Meditation techniques  (BREDESEN)
Adaptive immunity, insulin levels
            Visceral fat reduction
           
            SENS framework

1__Cell loss, cell atrophy
                                    Meditation techniques  (BREDESEN)
                                    EEG feedback, tDCS Apps(n-back etc)
                                    Homocysteine modification  Me-B12, MTHF, P5P; TMG if
Necessary  (BREDESEN)
Increase SirT1 function (BREDESEN) via resveratrol
(take target methods from within immune system above)
2__Nuclear epi-mutations
Fasting (caloric restriction), ketone body production via beta-hydroxybutyrate (BREDESEN)
Prolonged fast mimicking
3__Extracellular Crosslinks
            Fasting, ketone body production for glycation
                                    Homocysteine modification  Me-B12, MTHF, P5P; TMG if
Necessary  (BREDESEN)
4__mutant mitochondria
                                    CoQ or ubiquinol, α-lipoic acid, PQQ, NAC, ALCAR, Se, Zn, resveratrol, ascorbate,
thiamine
                        Heatshock therapy – Sauna, steam room
5__Immuno and cell senescence   
(take target methods from immune system, and organs to BBB above)
6__Intra cellular junk - glymphatic
            Resveratrol, Omega 3 pre bed
            Fast 12 hour per night, 3 hours before bed.
NOTE: see dangers of meltformin induced autophagy, should be taken with DHA – reference bartzokis and others.
7__Extra cellular junk
            Sleep (melatonin), SWS optimization. 8 hours min. melatonin
            Omega 3
            Reduce Ab via Curcumin, ashwagandha (BREDESEN)


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