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PROJECT BACKGROUND


Project zero MIND is an attempt to research and clinically evaluate treatment protocols that halt mid life neurodegeneration.   It is partly based on the findings of the late Dr George Bartzokis (1956-2014) UCLA Semel Institute for Neuroscience and Human Behavior 


Bartzokis key finding was that the brains myelination repair processes start to break down measurably from about age 35, causing us to become slower, less flexible and more forgetful.  More importantly he noticed that the pattern of degeneration across the brain in which this occurs start in the more complex and newly evolved areas (frontal lobe first) and progress in a way that actually resembles stages of dementia.



The types of proteins and the large volume of biological material involved in myelin breakdown are also implicated in overloading the brains neuroimmune system.   This overload is likely to cause immune stress in tandem with age increasing viral load and immunosenescence (immune cell atrophy and death).  So his proposal is that this gradual breakdown (which affects us all) sets the conditions (with other more widely known conditions) for dementia to occur.




In short there is very little that is actually beneficial from this entire process. Mid life slowing is actually the first stages of the gradual neurodegeneration that most of us will succumb to if we live long enough.  Most people will accept this as “natural” and perhaps engage in more brain training/health measures if their local government or health systems provide it.   For transhumanists maintenance of the brains condition is a fundamental priority and more rigorous methods and involvement are necessary which will be outlined on our “PROJECT DEVELOPMENT TIMELINE” page. The project title itself is inspired from the book "Why you are obsolete at almost every level and live largely in fiction"



Model Zero describes how the effect of the brain becoming more engrained in heuristics, inflexibility and restricted learning leads to exponential compounding whereby decades of this process result in a person being incapable and unable to deal with change.  The aim of the project is to foster collaboration within our own experimental population, using scientific methods to engage in and analyze a range of relevant mental rejuvenation activities and therapies (combination therapies).

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PROJECT ZERO MIND DEVELOPMENT TIMELINE

STAGE 1 SETUP Jan 2018 to May 2018 Model building stage (to be published) Base Lab setup Formal definition of problem (to be published) How to measure and target problem (to be published) STAGE 2 TRIAL RUN   May 2018 to January 2019 Initial working group setup Online collaboration and monitoring system Initial treatment regiments and methods agreed (to be published) STAGE 3 CONSOLIDATE RESULTS January 2019 Collate data Statistics Report summary of results (to be published)

BREDESEN PROTOCOL AND SENS FRAMEWORK

Cognitive decline is a sub discipline of Alzheimer's research and so benefits from a vast amount of clinical research which covers almost every known facet of the mind.  The approach employed here will be based on a refinement of the well known "Bredesen Protocol".    https://www.drbredesen.com/thebredesenprotocol The Bredesen Protocol is the only treatment which has reversed cognitive decline safely and consistently in clinical trials.   This approach posits Cognitive decline as a multi-factorial systems problem and targets each system with a separate treatment in combination. Many of these treatments involve simple and diet lifestyle adjustments while others involve readily available drugs and treatments.   This protocol is complex and extremely hard for those experiencing dementia to adhere to,  but is ideally suited for a younger age group aiming to address the problem at an early stage.   One of the aims of this project will be to ref

PROJECT ZERO MIND INTRODUCTION

Are you aged over 35 ? Have you perceived yourself to be less sharp, more forgetful, less cognitively flexible and less open to fundamental change than previously ? Because neurodegeneration starts in mid life and gradually increases over time, many of us don’t notice this till our 50’s and beyond.   During this gradual process most of can manage fine with acceptance and mental heuristics. Such as refining learned methods further and couching our inflexibility as a necessary part of maintaining our responsibilities and socioeconomic position. But what if we could actually slow this degeneration ? Would we actually find our progress accelerating and in the process become less prone to obsolescence? Would our mind be in far better condition for the future ? For further information see PROJECT BACKGROUND PROJECT DEVELOPMENT TIMELINE BIOLOGICAL TARGETS AND METHODS LIST BREDESEN PROTOCOL AND SENS FRAMEWORK PAPERS REPOSITORY  (Still to be added)